Trazodone Hydrochloride EP Impurity M CAS 157072-18-9 (cation form)
| CAS No. | 157072-18-9 (cation form) |
| Molecular Formula | C19H22ClN5O |
| Molecular Weight | 371.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trazodone Hydrochloride EP Impurity M.
As a process- or degradation-related impurity, Trazodone Hydrochloride EP Impurity M (CAS 157072-18-9 (cation form), C19H22ClN5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Trazodone Hydrochloride EP Impurity M (C19H22ClN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Trazodone Hydrochloride EP Impurity M meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN5O |
| Molecular Weight | 371.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Trazodone Standards
- Trazodone EP Impurity C (CAS 157072-19-0)
- Trazodone impurity 47 (CAS CATO-C4X-177247)
- Trazodone Impurity 58 (CAS 157072-20-3)
- Trazodone (CAS 19794-93-5)
- Trazodone impurity 51 (CAS CATO-C4X-177251)
- Trazodone Impurity 85 (CAS CATO-C4X-177285)
- Trazodone Impurity 110 (CAS CATO-C4X-1772110)
- Trazodone EP Impurity A (CAS 55290-68-1)
Recommended Standards
- Metoclopramide Impurity 127 (CAS CATO-C4X-1415127)
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- 6-((6-Chloro-2-methoxyacridin-9-yl)amino)hexanamide (CAS 77420-86-1)
- Amodiaquine Impurity 3 (CAS 102391-07-1)
- Azelnidipine Impurity 5 (CAS 103426-18-2)
- Calcitonin Impurity 27 (CAS CATO-C4X-221827)
- Gaspofungin Impurity F (CAS CATO-C4X-157521)
- 6-Fluoroisochroman (CAS 50396-63-9)
- 4-(2-(3-Iodophenyl)-2-oxoethyl)benzonitrile (CAS 146653-53-4)
- 4-(2,4-Dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-4-oxobutanoic acid (CAS 126802-57-1)
- 1-[5-(3-Chlorophenyl)isoxazol-3-yl]ethanol (CAS 657427-36-6)
- Cyclophosphamide Monohydrate (CAS 6055-19-2)
- 2,2’-Bipyridine-6,6’-dicarboxylic Acid (CAS 4479-74-7)
- Neuroendocrine Regulatory Peptide-4 (human, mouse, rat) (H-7266.1000) (CAS 922704-18-5)
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